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发布：2015-09-09 09:47 | 来源：网络整理 | 点击：次 | 责编：360好医师网

导读： Anti-DCAF12抗体--上海钰博生物科技有限公司

Anti-DCAF12抗体在一些特殊的实验里，只需要检测样本里的IgG或者IgM，常规的Anti-IgG (H+L)由于与IgG的重链和轻链都有结合反应，而IgG、IgM、IgA都有保守的轻链结构域，因此不能特异性的检测某种类型的IgG或者IgM。这时候就需要针对特殊类型Ig分子的二抗。艾美捷备有全面的二抗现货产品并能提供最完整的二抗产品线。主要二抗品牌为全球最大的二抗产品Jackson以及前沿抗体生产商EarthOx。按照标记分，有HRP、AP、生物素等标记二抗，好医师网，FITC、TRITC、Rhodamine、Cy3/5、Dylight等荧光二抗；按照检测物种分，有抗人、大鼠、小鼠、猪、驴、绵羊、山羊、小鸡、马、兔、仓鼠、狗、牛，以及多种细菌类二抗；另外，，还有IgG、IgA、IgM以及IgG(Fc)、IgG(ab’)2等不同类型抗体

产品编号 yb-9394R

英文名称 DCAF12

中文名称睾丸癌中心体相关蛋白抗体

别名 cancer/testis antigen 102; Centrosome-related protein TCC52; CT102; DCA12_HUMAN; DCAF12; DDB1- and CUL4-associated factor 12; TCC52; Testis cancer centrosome-related protein; WD repeat domain 40A; WD repeat-containing protein 40A; WDR40A.

Anti-DCAF12抗体

研究领域肿瘤细胞生物免疫学

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,

产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 51kDa

细胞定位细胞浆

性状 Lyophilized or Liquid

浓度 1mg/1ml

免疫原 KLH conjugated synthetic peptide derived from human DCAF12/WDR40A

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Anti-DCAF12抗体

产品介绍 background:
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR40A (WD-repeat-containing protein 40A), also known as DDB1- CUL4-associated factor 12, is a 453 amino acid cytoplasmic protein that contains four WD-repeats. WDR40A is highly expressed in some cancer cell lines, lung cancer tissues and normal testis. A probable substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex, WRD40A is suggested to interact with DDB1. WDR40A is encoded by a gene mapping to human chromosome 9p13.3. Human chromosome 9 houses over 900 genes and comprises nearly 4% of the human genome.

Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Subunit:
Interacts with DDB1.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.

Similarity:
Belongs to the WD repeat DCAF12 family.
Contains 4 WD repeats.

Anti-DCAF12抗体

yb-13331RGEMGTP结合丝裂原诱导T细胞蛋白抗体

yb-13332RGEMC1染色体卷曲螺旋域包含蛋白1抗体

yb-13333RGemin 6脊髓性肌萎缩症蛋白Gemin6抗体

yb-13336Rphospho-GFAP (Ser38)磷酸化胶质纤维酸性蛋白抗体

yb-13337RGFI1自主生长因子GFI1抗体

yb-10079RGPR109AG蛋白偶联受体109A抗体

yb-13343RGGA1γ-衔接蛋白相关蛋白1抗体

yb-13344RGGA2γ-衔接蛋白相关蛋白2抗体

yb-13345RGGA3γ-衔接蛋白相关蛋白3抗体

yb-13347RGGN配子生成素抗体

yb-13348RGGT2 heavy chainγ谷氨酰转肽酶2重链抗体